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Areas of Interest for Cancer Nanotechnology

Targeted nanomedicines for pancreatic cancer

Pancreatic cancer represents the 10th most common cause of new cancer and ranks fourth among cancer-related deaths in the United States. The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects. ...more »

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Areas of Interest for Cancer Nanotechnology

Cellular entry & exit of nanomaterials: biomedical applications

Apart from the various biomedical applications of nanomaterials, especially in cancer therapy, cellular uptake of nanoparticles is a key factor in recent years for efficient drug delivery applications. Researchers from all over the world focus mainly on cellular uptake of nanoparticles for efficient drug delivery applications, but according to my point, biocompatible cellular entry and exocytosis are the two key factors ...more »

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Areas of Interest for Cancer Nanotechnology

Clearance from liver

We have developed and studied ~100 different nanoconjugates (polymeric/metallic) for cancer imaging and therapy applications. Uptake by RES and retention in liver is a major drawback. We need to develop new technologies to clear these conjugates out from liver after sufficient time.

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Areas of Interest for Cancer Nanotechnology

Drug amphiphiles (DA) as their own delivery system.

In a recent breakthrough by Cui et. al drug amphiphiles were synthesized and they could effectively control the amount of drug in nanostructures but what missing from there was encapsulation of drug itself during self assembly of DA into nanostructures. They have synthesized nanofibers but as far i know by manipulating the concentration of amphiphiles during their self-assembly it is possible to control the type of nanostructure ...more »

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Areas of Interest for Cancer Nanotechnology

Multifunctinal or multitargeted nanoparticles

Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles ...more »

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Areas of Interest for Cancer Nanotechnology

Robust, Reproducible Methods for Making Targeted Nanoparticles

From an industry perspective, a potential bottleneck that will need to be overcome in bringing targeted nanoparticles from the bench to the bedside is scale-up. Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo). However, human studies and clinical use will require far greater quantity of targeted nanoparticles and ...more »

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Areas of Interest for Cancer Nanotechnology

Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology ...more »

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Areas of Interest for Cancer Nanotechnology

Nanorobotics: A Nanoengine For Cancer Treatment

Nano robots may serve as nano engines in driving the diagnosis and treatment of cancer in the future. It is an emerging tool that provides insightful simulators, improving its ease and use for biological purposes. This emerging tool may be useful for many health and scientific research applications. Current treatments like radiation therapy and chemotherapy often affect healthy cells more than cancerous cells, which can ...more »

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Areas of Interest for Cancer Nanotechnology

Nanoinformatics to accelerate translation of data to knowledge

Nanoinformatics involves the development of effective mechanisms for collecting, sharing, visualizing, modeling and analyzing information relevant to the nanoscale science community. It also involves the utilization of information and communication technologies that help to launch and support efficient communities of practice. Nanoinformatics is necessary for comparative characterization of nanomaterials, for design and ...more »

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Areas of Interest for Cancer Nanotechnology

Use of nanobuttons for treating cancer cells

Here we use nanobuttons that have the potential to target cancer cells before they reach the metastasis phase. As we known, most metastatic cancer occur in the lung,ovaries. We can bind nanobuttons with toxins inside to cancer cells after they bind to a particular site in the lungs or ovaries. When there is a mutation or factor associated with the cancer that results in the cancer-specific secretion of a protein, that ...more »

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Areas of Interest for Cancer Nanotechnology

A new nanotechnology based platform for cancer therapy

Theoretically, cancer can be cured if a potent drug acts only in the tumor with sufficient concentration and duration. Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood ...more »

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Areas of Interest for Cancer Nanotechnology

Therapeutic compound trafficking

Therapeutic compounds (TA) upon entering the systemic circulation undergo various clearance processes, which hinder the activity of the drug by either decreasing the amount of drug that reaches the site of action or by causing toxic side effects in various vital organs. To avoid this and to make sure the TA reaches the target site, a composite system could be composed that protects the TA from the clearance processes ...more »

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Areas of Interest for Cancer Nanotechnology

PRE DETERMINATION OF CANCER CELLS.

Using nanotechnology we can simulate the pattern of cancer cells at least 6 months before they become active. We need to find the origin of cancer cell production inside the body. This will give us an idea of how internal changes occur in cells when they are affected by cancer. We have now developed nanomaterials that can simulate how these cells change and provide fluorescent/magnetic imaging information.

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Areas of Interest for Cancer Nanotechnology

Retrospective study on Nanotechnology in medicine

Iron Oxide nanoparticles are effective contrast agents for MRI, over the years we have been saying this; every publication supports their effectiveness, but currently there is no commercially available nanoparticles solution for use as contrast agent. The lone survivor is Gastromark which is used orally and has diameter of 400 nanometers (not nano, the optimum size is 1-100 nm), the most promising "Ferridex I.V" was withdrawn ...more »

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Areas of Interest for Cancer Nanotechnology

bioactive delivery mechanisms

Many nanomaterial platforms are now available thanks to the great work funded during the last 10-20 years. As others have stated, improved targeted delivery to tissues/cells of interest is needed. Specifically, intracellular delivery of drugs such as siRNA that cannot withstand naked transport. Tighter integration of bionanomaterials such as engineered viruses and exosomes with other nano platforms could improve delivery ...more »

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Areas of Interest for Cancer Nanotechnology

Improving Tumor Targeting

Many of the current targeting approaches (antibody/Fab, etc.,) are dependent on the EPR (enhanced permeability and retention) effect and not designed to increase extravasation of nanomedicines from the systemic circulation to extracellular space around tumors. The use of current strategies, e.g., Her2, folate, etc., increase intracellular uptake, but have not had widespread success at increasing total tumor deposition ...more »

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Areas of Interest for Cancer Nanotechnology

Targeted Nanoparticles for Therapeutic Applications

The most important research questions that need to be addressed: Are targeted nanoparticles really reaching the site of action in required amounts? Quantification of nanoparticles or drug that reaches the site of action.

 

(idea received by e-mail)

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Areas of Interest for Cancer Nanotechnology

Particle Characterization and Formulation for Bulk Scale

Since, I am working in the area of cancer nanotechnology; I am much interested on NCI activities for discovering new nanoparticulate drug delivery systems and characterization of these systems.

 

The relevant areas of focus that need to be addressed include:

•Formulation of nanoparticles in bulk scale

•Actual biodistribution of nanoparticles

•Toxicity of nanoparticles

 

(idea received by e-mail)

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Areas of Interest for Cancer Nanotechnology

Need to change our focus from "Lab to Clinic" to "Clinic to Lab"

With the enormous knowledge, understanding of mechanism involving cancer, and myriads of nanotech based approaches; we should now apply these in reverse direction and fill the gap between nanotech based treatments in market and in lab.

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Areas of Interest for Cancer Nanotechnology

Platforms for delivery of biomolecules and pharmaceuticals

Consideration of existing and novel strategies for delivery of anticancer agents including drugs & biomolecules (such as nucleic acids and homing peptides). An area of drug delivery that deserves further focus and efforts is the development of on-demand drug delivery platforms applicable to patients.

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Areas of Interest for Cancer Nanotechnology

Nanotechnology for High-Throughput Biomarker Validation

The nanotechnology community needs to develop collaborations with researchers involved in biomarker discovery and develop and improve nanotechnology platforms that can be used for high-throughput validation of these potential biomarkers.

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