Welcome to our community.

In this community, you can submit ideas, vote on existing ideas, or add comments.

To submit an idea, please click the Submit New Idea button at the top of the navigation sidebar. You will then be asked to add a title and choose a campaign for the new idea. You will also have the option to add tags to the idea. To vote on an idea, simply click the up or down arrows to the right of the idea title/description. And to add a comment, click in the box below the idea.

If you would like to see all ideas created with a specific tag, you can click on the word or phrase via the tagcloud in the navigation sidebar area under "What we're discussing". You can also view ideas sorted by Campaigns from the right navigation area. To return to this page, click the All Ideas link.

Areas of Interest for Cancer Nanotechnology

Targeted nanomedicines for pancreatic cancer

Pancreatic cancer represents the 10th most common cause of new cancer and ranks fourth among cancer-related deaths in the United States. The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects. ...more »

Submitted by

Voting

0 votes
1 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Cellular entry & exit of nanomaterials: biomedical applications

Apart from the various biomedical applications of nanomaterials, especially in cancer therapy, cellular uptake of nanoparticles is a key factor in recent years for efficient drug delivery applications. Researchers from all over the world focus mainly on cellular uptake of nanoparticles for efficient drug delivery applications, but according to my point, biocompatible cellular entry and exocytosis are the two key factors ...more »

Submitted by

Voting

1 vote
1 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Clearance from liver

We have developed and studied ~100 different nanoconjugates (polymeric/metallic) for cancer imaging and therapy applications. Uptake by RES and retention in liver is a major drawback. We need to develop new technologies to clear these conjugates out from liver after sufficient time.

Submitted by

Voting

3 votes
3 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Drug amphiphiles (DA) as their own delivery system.

In a recent breakthrough by Cui et. al drug amphiphiles were synthesized and they could effectively control the amount of drug in nanostructures but what missing from there was encapsulation of drug itself during self assembly of DA into nanostructures. They have synthesized nanofibers but as far i know by manipulating the concentration of amphiphiles during their self-assembly it is possible to control the type of nanostructure ...more »

Submitted by

Voting

1 vote
2 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Multifunctinal or multitargeted nanoparticles

Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles ...more »

Submitted by

Voting

4 votes
5 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Robust, Reproducible Methods for Making Targeted Nanoparticles

From an industry perspective, a potential bottleneck that will need to be overcome in bringing targeted nanoparticles from the bench to the bedside is scale-up. Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo). However, human studies and clinical use will require far greater quantity of targeted nanoparticles and ...more »

Submitted by

Voting

6 votes
6 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology ...more »

Submitted by

Voting

8 votes
8 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Nanorobotics: A Nanoengine For Cancer Treatment

Nano robots may serve as nano engines in driving the diagnosis and treatment of cancer in the future. It is an emerging tool that provides insightful simulators, improving its ease and use for biological purposes. This emerging tool may be useful for many health and scientific research applications. Current treatments like radiation therapy and chemotherapy often affect healthy cells more than cancerous cells, which can ...more »

Submitted by

Voting

1 vote
2 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

More focus on the use of nanotechnology for metastasis therapy

currently the tumor treatment studies are restricted to primary tumors but very little is being done to understand nanoparticle routing and penetration of metastatic site

Submitted by

Voting

8 votes
8 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Nanoinformatics to accelerate translation of data to knowledge

Nanoinformatics involves the development of effective mechanisms for collecting, sharing, visualizing, modeling and analyzing information relevant to the nanoscale science community. It also involves the utilization of information and communication technologies that help to launch and support efficient communities of practice. Nanoinformatics is necessary for comparative characterization of nanomaterials, for design and ...more »

Submitted by

Voting

23 votes
24 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Use of nanobuttons for treating cancer cells

Here we use nanobuttons that have the potential to target cancer cells before they reach the metastasis phase. As we known, most metastatic cancer occur in the lung,ovaries. We can bind nanobuttons with toxins inside to cancer cells after they bind to a particular site in the lungs or ovaries. When there is a mutation or factor associated with the cancer that results in the cancer-specific secretion of a protein, that ...more »

Submitted by

Voting

2 votes
4 up votes
2 down votes
Active

Areas of Interest for Cancer Nanotechnology

A new nanotechnology based platform for cancer therapy

Theoretically, cancer can be cured if a potent drug acts only in the tumor with sufficient concentration and duration. Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood ...more »

Submitted by

Voting

3 votes
4 up votes
1 down votes
Active