Therapeutic compounds (TA) upon entering the systemic circulation undergo various clearance processes, which hinder the activity of the drug by either decreasing the amount of drug that reaches the site of action or by causing toxic side effects in various vital organs. To avoid this and to make sure the TA reaches the target site, a composite system could be composed that protects the TA from the clearance processes of the body and protects the body's vital organs from the TA's toxic side effects. This composite system with a targeting moiety will travel in the systemic circulation until reaches its target where a bond can be cleaved to release the appropriate payload at the site of action. This requires the orchestrated effort of multidisciplinary scientists in the field.
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