Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles and the concentration of nanoparticles that is effectively translocated into cells, this system could be beneficial.
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