Areas of Interest for Cancer Nanotechnology

Areas of Interest for Cancer Nanotechnology

Reduce immune responses to nucleic acid therapies

We need research into ways to use nanotechnology to overcome immune responses to nucleic acid therapies.

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Areas of Interest for Cancer Nanotechnology

Tumor models with well-characterized tumor vasculature/pore size

It is critical and necessary to understand the tumor vasculature/pore size of xenograft/orthotopic/metastatic/GEMMs to correlate efficacy of novel nanotherapeutics.

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Areas of Interest for Cancer Nanotechnology

Nanotechnology for High-Throughput Biomarker Validation

The nanotechnology community needs to develop collaborations with researchers involved in biomarker discovery and develop and improve nanotechnology platforms that can be used for high-throughput validation of these potential biomarkers.

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Nanotechnology and the tumor microenvironment

Does nanotechnology offer unique opportunities to alter or influence the tumor microenvironment to suppress progression and invasion?

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Nanotechnology for Early/Circulating Tumor Detection

We need innovative technologies for early detecting of cancer at ultra-high sensitivities and to use similar strategies to detect small quantities of circulating tumor cells

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Platforms for delivery of biomolecules and pharmaceuticals

Consideration of existing and novel strategies for delivery of anticancer agents including drugs & biomolecules (such as nucleic acids and homing peptides). An area of drug delivery that deserves further focus and efforts is the development of on-demand drug delivery platforms applicable to patients.

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Need to change our focus from "Lab to Clinic" to "Clinic to Lab"

With the enormous knowledge, understanding of mechanism involving cancer, and myriads of nanotech based approaches; we should now apply these in reverse direction and fill the gap between nanotech based treatments in market and in lab.

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high contrast imaging by use of optical crosstalk-Nanobiosensor

in this method firefly algorithm can be used. therefore by use of optical communication among agents, the most of injected nanoparticle will be reached to target point and then the brightness of target area intensely increased.

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Particle Characterization and Formulation for Bulk Scale

Since, I am working in the area of cancer nanotechnology; I am much interested on NCI activities for discovering new nanoparticulate drug delivery systems and characterization of these systems.

 

The relevant areas of focus that need to be addressed include:

•Formulation of nanoparticles in bulk scale

•Actual biodistribution of nanoparticles

•Toxicity of nanoparticles

 

(idea received by e-mail)

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Areas of Interest for Cancer Nanotechnology

Targeted Nanoparticles for Therapeutic Applications

The most important research questions that need to be addressed: Are targeted nanoparticles really reaching the site of action in required amounts? Quantification of nanoparticles or drug that reaches the site of action.

 

(idea received by e-mail)

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Improving Tumor Targeting

Many of the current targeting approaches (antibody/Fab, etc.,) are dependent on the EPR (enhanced permeability and retention) effect and not designed to increase extravasation of nanomedicines from the systemic circulation to extracellular space around tumors. The use of current strategies, e.g., Her2, folate, etc., increase intracellular uptake, but have not had widespread success at increasing total tumor deposition ...more »

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bioactive delivery mechanisms

Many nanomaterial platforms are now available thanks to the great work funded during the last 10-20 years. As others have stated, improved targeted delivery to tissues/cells of interest is needed. Specifically, intracellular delivery of drugs such as siRNA that cannot withstand naked transport. Tighter integration of bionanomaterials such as engineered viruses and exosomes with other nano platforms could improve delivery ...more »

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