We have developed and studied ~100 different nanoconjugates (polymeric/metallic) for cancer imaging and therapy applications. Uptake by RES and retention in liver is a major drawback. We need to develop new technologies to clear these conjugates out from liver after sufficient time.
Theoretically, cancer can be cured if a potent drug acts only in the tumor with sufficient concentration and duration. Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood ...more »