Areas of Interest for Cancer Nanotechnology

Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology... more »

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Areas of Interest for Cancer Nanotechnology

Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology... more »

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Areas of Interest for Cancer Nanotechnology

Nanorobotics: A Nanoengine For Cancer Treatment

Nano robots may serve as nano engines in driving the diagnosis and treatment of cancer in the future. It is an emerging tool that provides insightful simulators, improving its ease and use for biological purposes. This emerging tool may be useful for many health and scientific research applications. Current treatments like radiation therapy and chemotherapy often affect healthy cells more than cancerous cells, which can... more »

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Areas of Interest for Cancer Nanotechnology

Nanoinformatics to accelerate translation of data to knowledge

Nanoinformatics involves the development of effective mechanisms for collecting, sharing, visualizing, modeling and analyzing information relevant to the nanoscale science community. It also involves the utilization of information and communication technologies that help to launch and support efficient communities of practice. Nanoinformatics is necessary for comparative characterization of nanomaterials, for design and... more »

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Areas of Interest for Cancer Nanotechnology

Use of nanobuttons for treating cancer cells

Here we use nanobuttons that have the potential to target cancer cells before they reach the metastasis phase. As we known, most metastatic cancer occur in the lung,ovaries. We can bind nanobuttons with toxins inside to cancer cells after they bind to a particular site in the lungs or ovaries. When there is a mutation or factor associated with the cancer that results in the cancer-specific secretion of a protein, that... more »

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Areas of Interest for Cancer Nanotechnology

A new nanotechnology based platform for cancer therapy

Theoretically, cancer can be cured if a potent drug acts only in the tumor with sufficient concentration and duration. Nanotechnology has the potential to satisfy these requirements if some of its intrinsic shortcomings can be solved: rapid uptake of nanocarriers by RES and the toxicity as a result, and drug release outside the tumor, especially the early burst release when the fast drug release is coupled with high blood... more »

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A new nanotechnology based plateform for cancer therapy

Cancer can be cured if a potent drug acts only in tumor with high enough dose and duration. Nanotechnology has this potential if its intrinsic shortcomings can be solved: rapid uptake by RES and toxicity as a result, and drug release outside tumor especially the early burst release, when the fast drug release is coupled with high blood concentration of the carrier. A new strategy can overcome these shortcomings, Prodrug-Encapsulated... more »

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Areas of Interest for Cancer Nanotechnology

Therapeutic compound trafficking

Therapeutic compounds (TA) upon entering the systemic circulation undergo various clearance processes, which hinder the activity of the drug by either decreasing the amount of drug that reaches the site of action or by causing toxic side effects in various vital organs. To avoid this and to make sure the TA reaches the target site, a composite system could be composed that protects the TA from the clearance processes... more »

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PRE DETERMINATION OF CANCER CELLS.

Using nanotechnology we can simulate the pattern of cancer cells at least 6 months before they become active. We need to find the origin of cancer cell production inside the body. This will give us an idea of how internal changes occur in cells when they are affected by cancer. We have now developed nanomaterials that can simulate how these cells change and provide fluorescent/magnetic imaging information.

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Retrospective study on Nanotechnology in medicine

Iron Oxide nanoparticles are effective contrast agents for MRI, over the years we have been saying this; every publication supports their effectiveness, but currently there is no commercially available nanoparticles solution for use as contrast agent. The lone survivor is Gastromark which is used orally and has diameter of 400 nanometers (not nano, the optimum size is 1-100 nm), the most promising "Ferridex I.V" was withdrawn... more »

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bioactive delivery mechanisms

Many nanomaterial platforms are now available thanks to the great work funded during the last 10-20 years. As others have stated, improved targeted delivery to tissues/cells of interest is needed. Specifically, intracellular delivery of drugs such as siRNA that cannot withstand naked transport. Tighter integration of bionanomaterials such as engineered viruses and exosomes with other nano platforms could improve delivery... more »

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Areas of Interest for Cancer Nanotechnology

Improving Tumor Targeting

Many of the current targeting approaches (antibody/Fab, etc.,) are dependent on the EPR (enhanced permeability and retention) effect and not designed to increase extravasation of nanomedicines from the systemic circulation to extracellular space around tumors. The use of current strategies, e.g., Her2, folate, etc., increase intracellular uptake, but have not had widespread success at increasing total tumor deposition... more »

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