Areas of Interest for Cancer Nanotechnology

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Nanoinformatics to accelerate translation of data to knowledge

Nanoinformatics involves the development of effective mechanisms for collecting, sharing, visualizing, modeling and analyzing information relevant to the nanoscale science community. It also involves the utilization of information and communication technologies that help to launch and support efficient communities of practice. Nanoinformatics is necessary for comparative characterization of nanomaterials, for design and ...more »

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Areas of Interest for Cancer Nanotechnology

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Improving Tumor Targeting

Many of the current targeting approaches (antibody/Fab, etc.,) are dependent on the EPR (enhanced permeability and retention) effect and not designed to increase extravasation of nanomedicines from the systemic circulation to extracellular space around tumors. The use of current strategies, e.g., Her2, folate, etc., increase intracellular uptake, but have not had widespread success at increasing total tumor deposition ...more »

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Areas of Interest for Cancer Nanotechnology

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Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology ...more »

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Areas of Interest for Cancer Nanotechnology

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Robust, Reproducible Methods for Making Targeted Nanoparticles

From an industry perspective, a potential bottleneck that will need to be overcome in bringing targeted nanoparticles from the bench to the bedside is scale-up. Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo). However, human studies and clinical use will require far greater quantity of targeted nanoparticles and ...more »

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Retrospective study on Nanotechnology in medicine

Iron Oxide nanoparticles are effective contrast agents for MRI, over the years we have been saying this; every publication supports their effectiveness, but currently there is no commercially available nanoparticles solution for use as contrast agent. The lone survivor is Gastromark which is used orally and has diameter of 400 nanometers (not nano, the optimum size is 1-100 nm), the most promising "Ferridex I.V" was withdrawn ...more »

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Areas of Interest for Cancer Nanotechnology

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Multifunctinal or multitargeted nanoparticles

Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles ...more »

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