Areas of Interest for Cancer Nanotechnology

Areas of Interest for Cancer Nanotechnology

Nanoinformatics to accelerate translation of data to knowledge

Nanoinformatics involves the development of effective mechanisms for collecting, sharing, visualizing, modeling and analyzing information relevant to the nanoscale science community. It also involves the utilization of information and communication technologies that help to launch and support efficient communities of practice. Nanoinformatics is necessary for comparative characterization of nanomaterials, for design and ...more »

Submitted by
5 comments

Voting

23 votes
24 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Targeted Nanoparticles for Therapeutic Applications

The most important research questions that need to be addressed: Are targeted nanoparticles really reaching the site of action in required amounts? Quantification of nanoparticles or drug that reaches the site of action.

 

(idea received by e-mail)

Submitted by
7 comments

Voting

14 votes
15 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Improving Tumor Targeting

Many of the current targeting approaches (antibody/Fab, etc.,) are dependent on the EPR (enhanced permeability and retention) effect and not designed to increase extravasation of nanomedicines from the systemic circulation to extracellular space around tumors. The use of current strategies, e.g., Her2, folate, etc., increase intracellular uptake, but have not had widespread success at increasing total tumor deposition ...more »

Submitted by
2 comments

Voting

9 votes
9 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

More focus on the use of nanotechnology for metastasis therapy

currently the tumor treatment studies are restricted to primary tumors but very little is being done to understand nanoparticle routing and penetration of metastatic site

Submitted by
1 comment

Voting

8 votes
8 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Fundamental mechanisms of nanoparticle drug delivery

We are developing nanoparticle drugs based on a very limited understanding of how nanoparticles are transported from vascular circulation into solid tumors. We do not know what cell types, microenvironments, or biological molecules mediate this effect in humans, what cell types take up delivered agents, and how our animal models correlate with human tumors in these respects. Mechanistic studies and comparative pathology ...more »

Submitted by
2 comments

Voting

8 votes
8 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Platforms for delivery of biomolecules and pharmaceuticals

Consideration of existing and novel strategies for delivery of anticancer agents including drugs & biomolecules (such as nucleic acids and homing peptides). An area of drug delivery that deserves further focus and efforts is the development of on-demand drug delivery platforms applicable to patients.

Submitted by
1 comment

Voting

6 votes
6 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Robust, Reproducible Methods for Making Targeted Nanoparticles

From an industry perspective, a potential bottleneck that will need to be overcome in bringing targeted nanoparticles from the bench to the bedside is scale-up. Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo). However, human studies and clinical use will require far greater quantity of targeted nanoparticles and ...more »

Submitted by
Add your comment

Voting

6 votes
6 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Reduce immune responses to nucleic acid therapies

We need research into ways to use nanotechnology to overcome immune responses to nucleic acid therapies.

Submitted by
1 comment

Voting

5 votes
5 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Retrospective study on Nanotechnology in medicine

Iron Oxide nanoparticles are effective contrast agents for MRI, over the years we have been saying this; every publication supports their effectiveness, but currently there is no commercially available nanoparticles solution for use as contrast agent. The lone survivor is Gastromark which is used orally and has diameter of 400 nanometers (not nano, the optimum size is 1-100 nm), the most promising "Ferridex I.V" was withdrawn ...more »

Submitted by
Add your comment

Voting

4 votes
4 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Multifunctinal or multitargeted nanoparticles

Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles ...more »

Submitted by
1 comment

Voting

4 votes
5 up votes
1 down votes
Active

Areas of Interest for Cancer Nanotechnology

Nanotechnology for High-Throughput Biomarker Validation

The nanotechnology community needs to develop collaborations with researchers involved in biomarker discovery and develop and improve nanotechnology platforms that can be used for high-throughput validation of these potential biomarkers.

Submitted by
2 comments

Voting

3 votes
3 up votes
0 down votes
Active

Areas of Interest for Cancer Nanotechnology

Nanotechnology and the tumor microenvironment

Does nanotechnology offer unique opportunities to alter or influence the tumor microenvironment to suppress progression and invasion?

Submitted by
3 comments

Voting

3 votes
4 up votes
1 down votes
Active