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Areas of Interest for Cancer Nanotechnology

Particle Characterization and Formulation for Bulk Scale

Since, I am working in the area of cancer nanotechnology; I am much interested on NCI activities for discovering new nanoparticulate drug delivery systems and characterization of these systems.

 

The relevant areas of focus that need to be addressed include:

•Formulation of nanoparticles in bulk scale

•Actual biodistribution of nanoparticles

•Toxicity of nanoparticles

 

(idea received by e-mail)

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Areas of Interest for Cancer Nanotechnology

bioactive delivery mechanisms

Many nanomaterial platforms are now available thanks to the great work funded during the last 10-20 years. As others have stated, improved targeted delivery to tissues/cells of interest is needed. Specifically, intracellular delivery of drugs such as siRNA that cannot withstand naked transport. Tighter integration of bionanomaterials such as engineered viruses and exosomes with other nano platforms could improve delivery... more »

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Areas of Interest for Cancer Nanotechnology

Use of nanobuttons for treating cancer cells

Here we use nanobuttons that have the potential to target cancer cells before they reach the metastasis phase. As we known, most metastatic cancer occur in the lung,ovaries. We can bind nanobuttons with toxins inside to cancer cells after they bind to a particular site in the lungs or ovaries. When there is a mutation or factor associated with the cancer that results in the cancer-specific secretion of a protein, that... more »

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Areas of Interest for Cancer Nanotechnology

Therapeutic compound trafficking

Therapeutic compounds (TA) upon entering the systemic circulation undergo various clearance processes, which hinder the activity of the drug by either decreasing the amount of drug that reaches the site of action or by causing toxic side effects in various vital organs. To avoid this and to make sure the TA reaches the target site, a composite system could be composed that protects the TA from the clearance processes... more »

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Areas of Interest for Cancer Nanotechnology

Nanorobotics: A Nanoengine For Cancer Treatment

Nano robots may serve as nano engines in driving the diagnosis and treatment of cancer in the future. It is an emerging tool that provides insightful simulators, improving its ease and use for biological purposes. This emerging tool may be useful for many health and scientific research applications. Current treatments like radiation therapy and chemotherapy often affect healthy cells more than cancerous cells, which can... more »

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Areas of Interest for Cancer Nanotechnology

Drug amphiphiles (DA) as their own delivery system.

In a recent breakthrough by Cui et. al drug amphiphiles were synthesized and they could effectively control the amount of drug in nanostructures but what missing from there was encapsulation of drug itself during self assembly of DA into nanostructures. They have synthesized nanofibers but as far i know by manipulating the concentration of amphiphiles during their self-assembly it is possible to control the type of nanostructure... more »

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Areas of Interest for Cancer Nanotechnology

Cellular entry & exit of nanomaterials: biomedical applications

Apart from the various biomedical applications of nanomaterials, especially in cancer therapy, cellular uptake of nanoparticles is a key factor in recent years for efficient drug delivery applications. Researchers from all over the world focus mainly on cellular uptake of nanoparticles for efficient drug delivery applications, but according to my point, biocompatible cellular entry and exocytosis are the two key factors... more »

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Areas of Interest for Cancer Nanotechnology

Targeted nanomedicines for pancreatic cancer

Pancreatic cancer represents the 10th most common cause of new cancer and ranks fourth among cancer-related deaths in the United States. The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.... more »

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PRE DETERMINATION OF CANCER CELLS.

Using nanotechnology we can simulate the pattern of cancer cells at least 6 months before they become active. We need to find the origin of cancer cell production inside the body. This will give us an idea of how internal changes occur in cells when they are affected by cancer. We have now developed nanomaterials that can simulate how these cells change and provide fluorescent/magnetic imaging information.

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