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In a recent breakthrough by Cui et. al drug amphiphiles were synthesized and they could effectively control the amount of drug in nanostructures but what missing from there was encapsulation of drug itself during self assembly of DA into nanostructures. They have synthesized nanofibers but as far i know by manipulating the concentration of amphiphiles during their self-assembly it is possible to control the type of nanostructure ...more »
Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells. We may use TAT peptide or gene delivery systems (for endoosmolysis) for effective translocation of cargo inside cells and antibody for binding. This system is complex but with optimization of the concentration of ligands on the surface on nanoparticles ...more »
Iron Oxide nanoparticles are effective contrast agents for MRI, over the years we have been saying this; every publication supports their effectiveness, but currently there is no commercially available nanoparticles solution for use as contrast agent. The lone survivor is Gastromark which is used orally and has diameter of 400 nanometers (not nano, the optimum size is 1-100 nm), the most promising "Ferridex I.V" was withdrawn ...more »
With the enormous knowledge, understanding of mechanism involving cancer, and myriads of nanotech based approaches; we should now apply these in reverse direction and fill the gap between nanotech based treatments in market and in lab.